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Patients should avoid making rapid dietary changes or severely restricting food intake beyond what naturally occurs from reduced appetite, as extreme caloric restriction can worsen gastrointestinal symptoms and compromise nutritional status

This forces the cardiovascular system to work harder during physical activity, leading to muscle fatigue and soreness

One case report states that the recovery of the products of oxidative metabolism in a child was 12% following overdose compared to an expected rate of 3543% reported in adults

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